1,3 di fluoro benzene

Product Description

13Difluorobenzene is a fluorinated aromatic compound with two fluorine atoms positioned at the 1 and 3 positions of a benzene ring meaning it is a metasubstituted benzene derivative This compound is useful in a variety of chemical and pharmaceutical applications particularly in the synthesis of other fluorinated compounds

 Chemical Details

 IUPAC Name 13Difluorobenzene  

 Molecular Formula C6H4F2  

 Molecular Weight 11410 gmol  

 Structure

   Benzene ring C6H5 with two fluorine atoms attached at positions 1 and 3 relative to each other

 Physical Properties

 Appearance Colorless liquid at room temperature  

 Boiling Point  115117C  

 Melting Point 22C  

 Density 123 gcm at 25C  

 Solubility Slightly soluble in water but soluble in organic solvents like ethanol acetone and ether

 Applications

1 Pharmaceuticals and Agrochemicals

    Fluorinated aromatic compounds like 13difluorobenzene are valuable intermediates in the synthesis of more complex molecules with biological activity

    Used in the development of fluorinecontaining drugs or agrochemicals where the introduction of fluorine enhances metabolic stability and lipophilicity

2 Chemical Synthesis

    Precursors to Fluorinated Aromatics 13difluorobenzene is commonly used in the preparation of other fluorinated aromatic compounds such as fluorophenols fluorobenzyl alcohols and fluorinated polymers

    Electrophilic Substitution Reactions It is useful in electrophilic aromatic substitution reactions where the fluorine atoms influence the reactivity of the benzene ring

3 Materials Science

    Used as a building block in the synthesis of highperformance materials like fluorinated polymers or liquid crystals with tailored properties for electronic applications

 Chemical Reactivity

1 Electrophilic Substitution

    The fluorine atoms are electronwithdrawing and deactivating towards electrophilic substitution at the ortho and para positions relative to the fluorines However they activate substitution at the meta position making 13difluorobenzene useful for specific reactions

2 Reactivity with Nucleophiles

    13Difluorobenzene may react with nucleophilic reagents like Grignard reagents organolithium compounds or other nucleophiles to form various substituted benzene derivatives

3 Reduction Reactions

    Can undergo reduction to form hydroxybenzene derivatives or other reduced aromatic products depending on the reaction conditions

 Synthesis

 Fluorination of Benzene  

  13Difluorobenzene can be synthesized by selective fluorination of benzene using fluorinating agents like fluorine gas F2 or potassium bifluoride KHF2 in the presence of a catalyst or heat Specific reagents and conditions allow for selective substitution at the 13 positions on the benzene ring

 Safety and Handling

 Toxicity  

   Can be irritating to the eyes skin and respiratory system  

   Prolonged exposure may have harmful effects Always handle with care in a wellventilated environment

 Precautions  

   Use gloves safety glasses and work in a fume hood to avoid inhaling vapors or coming into contact with the compound

 Storage  

   Store in tightly sealed containers in a cool dry place away from sources of heat and strong oxidizing agents

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