1-(2-(2-Hydroxy Ethoxy)-ethyl) Piperazine (HEEP)

Product Description

122Hydroxyethoxyethylpiperazine HEEP is a piperazine derivative commonly used as an intermediate in organic synthesis particularly in the pharmaceutical and polymer industries

 Chemical Details

 IUPAC Name 122Hydroxyethoxyethylpiperazine  

 Molecular Formula C8H18N2O2  

 Molecular Weight 17424 gmol  

 Structure

   A piperazine ring substituted at one nitrogen atom with a hydroxyethoxyethyl group

   Contains both a hydroxyl group OH and ether O functionalities

 Physical Properties

 Appearance Clear to pale yellow liquid at room temperature  

 Boiling Point 270C decomposes  

 Solubility Highly soluble in water and polar organic solvents like methanol ethanol and acetone  

 Density 108 gcm at 25C

 Applications

1 Pharmaceutical Intermediate

    Widely used as a building block in the synthesis of drugs especially those targeting the central nervous system CNS

    Functional groups on HEEP make it useful for introducing polar and hydrophilic properties to drug molecules

2 Polymer and Material Science

    Epoxy Resins Used as a curing agent for epoxy resins to improve flexibility and hydrophilicity

    Polyurethane Synthesis Acts as a chain extender in polyurethane formulations

3 Chemical Research

    Serves as a ligand or a precursor in coordination chemistry

    Utilized in the synthesis of surfactants detergents and stabilizers

 Chemical Reactivity

1 Hydroxyl Group

    Can participate in typical reactions such as esterification etherification or crosslinking

2 Ether Group

    Provides flexibility and hydrophilicity but is relatively inert chemically

3 Piperazine Nitrogen Atoms

    Act as nucleophiles in substitution reactions

    Can coordinate with metals or undergo alkylation or acylation

 Synthesis of HEEP

Typically synthesized through the reaction of piperazine with ethylene oxide or ethylene glycol derivatives

1 Step 1 Reaction of piperazine with ethylene glycol or ethylene chlorohydrin in the presence of a base to form the hydroxyethoxyethylpiperazine derivative

2 Step 2 Purification using distillation or recrystallization

 Safety and Handling

 Toxicity

   Mildly toxic can cause irritation to the skin eyes and respiratory tract

   Handle with care avoiding direct contact or inhalation of vapors

 Precautions

   Use gloves safety glasses and work in a wellventilated area or fume hood

   Store in a cool dry place away from strong oxidizing agents

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