(R)-(+) alpha-phenylethylamine

Product Description

RPhenylethylamine also known as R1phenylethanamine is a chiral amine with significant roles in organic chemistry pharmaceuticals and as a biochemical precursor Heres a detailed overview

 Chemical Details

 Molecular Formula C8H11N  

 Molecular Weight 12118 gmol  

 Structure

   A phenyl ring attached to a chiral ethylamine group

   The Rconfiguration refers to the specific spatial arrangement of substituents around the chiral center

 Physical Properties

   Appearance Colorless to pale yellow liquid

   Boiling Point 185C

   Optical Rotation Positive D value depends on the solvent and concentration

 Biochemical and Pharmacological Context

1 Natural Occurrence

    Phenylethylamine is a trace amine found in small amounts in the human brain and other tissues It plays a role in modulating neurotransmitter systems particularly dopamine and serotonin

2 Activity of the REnantiomer

    The Renantiomer often has specific binding properties with enzymes and receptors compared to its Scounterpart This stereospecific interaction can influence its pharmacological effects

3 Potential Applications

    Neuromodulation Acts as a stimulant of the central nervous system CNS by influencing catecholamine signaling

    Drug Precursor Used in the synthesis of pharmaceutical compounds including decongestants antidepressants and weight loss drugs

 Applications in Organic Synthesis

 Chiral Building Block  

   Its amine functionality and chirality make it a valuable intermediate for synthesizing enantiomerically pure drugs and materials

 Resolution of Racemic Mixtures  

   Often resolved from racemic phenylethylamine using chiral acids eg tartaric acid or asymmetric synthesis

 Pharmaceutical and Industrial Uses

 Pharmacological Research  

    Studies focus on its psychoactive effects and its role as a neuromodulator

 Intermediate in Drug Development  

    Derivatives are used in developing sympathomimetic drugs and other therapeutic agents

 Custom Synthesis  

    Key in synthesizing compounds with adrenergic receptor activity

 Safety and Handling

 Toxicity May cause irritation to the skin eyes or respiratory system upon exposure Psychoactive effects at high doses

 Precautions Handle in a wellventilated environment using gloves and protective eyewear

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