(R)-(-)-3-(Carbamoylmethyl)- 5-methyl hexanoic acid (RCMH)

Product Description

R3Carbamoylmethyl5methyl hexanoic acid RCMH is the enantiomerically pure Rform of the compound indicating it is optically active and contains only the Rconfiguration at its chiral center This compound is of interest in medicinal chemistry particularly for its potential role in modulating neurological processes

 Structural and Chemical Details

 Chemical formula C10H19NO3  

 Molecular weight 20126 gmol  

 Chirality The Rconfiguration specifies the spatial arrangement of the groups around the chiral center

 Functional Groups

   Carboxylic Acid COOH Imparts acidity and potential for forming salts or esters

   Carbamoylmethyl Group CH2CONH2 Contributes to hydrogen bonding and potential interactions with biological targets

   Methyl Substituent Located on the hexanoic acid backbone influencing hydrophobicity and steric interactions

 Pharmaceutical Context

1 Neurological Activity  

   Similar compounds eg pregabalin act as GABA analogs modulating calcium channels 2 subunit to treat neuropathic pain epilepsy and anxiety The Renantiomer is often the active form in such cases due to stereospecific receptor interactions

2 Enantiomeric Purity  

   The pharmacological activity and metabolism of chiral compounds can be heavily influenced by their configuration The Renantiomer may exhibit distinct bioactivity compared to the racemic mixture or the Sform

 Potential Applications

 Therapeutic Research The compound may be explored for its role in

   Neuropathic pain management

   Seizure modulation

   Anxiety treatment

 Drug Development Used as a lead compound or intermediate for synthesizing derivatives with improved potency bioavailability or safety

 Synthesis

The synthesis of R3Carbamoylmethyl5methyl hexanoic acid typically involves

1 Chiral Resolution Separating the R and Senantiomers from a racemic mixture

2 Asymmetric Synthesis Employing chiral catalysts or reagents to selectively produce the Renantiomer

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